Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Mesenchymal stem cells (MSCs) have captured great attention in regenerative treatment for more than decades based on their differentiation capacity, strong immunomodulator properties, and their ability to be kululiped and manipulated. The recent investigation implies that the MSCS pleiotropic effect is not related to their differentiation capabilities, but is more mediated by the secretion of soluble paracrine factors. Exosom, nano extracellular vesicles, is one of these paracrine mediators.

Exosom functional cargo transfers such as MIRNA and MRNA molecules, peptides, protein, cytokines, and lipids from MSc to the recipient’s cell. Exocomic participates in communication events between cells and contributes to healing tissues and injured organs. Studies report that exosom alone is responsible for the therapeutic effect of MSC in various experimental models. Therefore, the exosom derived MSC can be manipulated and applied to establish a new cell-free therapeutic approach to the treatment of various diseases including the heart, kidney, liver, immune, and neurological disease, and healing of skin wounds. Compared to their donor cells, the exosom derived MSC offers more stable entities and reduced risk of safety regarding living cell administration, eg. Microvascular occlusion risk.

This review discusses the exosome insulation method found and utilized in clinical settings so far and present the latest information summary of the MSC exosomes in the treatment of translation. Exosom is an extracellular type of vesicle (EVS) issued by several types of mammal cells and involved in communication between cells. A number of studies have explored the potential diagnostic and exosomal therapeutic. The main challenge is the lack of standard and standard techniques for insulation and analysis of downstream nanovesicles. Conventional insulation method, such as ultracentrification, precipitation, filtration, chromatography, and an immune affinity-based approach, depends on certain physical properties or in surface biomarkers. However, one of the existing methods has limitations. Various parameters, such as efficacy, specificity, labor input, cost and scalability, and standardization options, must be considered for the appropriate approach.

The communication of extracellular vesicles between mesenchymal stroma cells and immune effect cells

Mesenchymal Stem / Stromal Cell (MSCS) is a multiphotic cell that is on the body’s stroma network and is able to promote network repair and weaken the inflammatory process through its immunomodulatory properties. Preclinical and clinical observations reveal that it is not only inter-cell communication that directly mediates MSC property; In fact, an important role is also played by the release of soluble and bioactive factors, such as cytokines, growth factors and extracellular vesicles (EVs). EVS is a membrane plated vesicel that contains various kinds of bioactive molecules, including lipids, proteins, and nucleic acids, such as RNA.

EVS let go of their content into target cells, thus affecting the fate of cells through intracellular process control. In addition, EV which is revealed MSC can mediate the effect of modulation towards different effector cells belonging to innate and adaptive immunity. In this review, we will discuss the literature data on EVS obtained by MSC, including the current standard method for their isolation and characterization, the mechanism that supports its immunoregulator properties, and their potential clinical applications as an alternative MSc-based therapy for inflammatory reactions, such as grafting disease Versus-hosted (GVHD).

 Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine
Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Large extracellular vesicles can be characterized by multiplex labeling using imaging flow cytometry

The extracellular vesicles (EVS) are heterogeneous (30 Nm-10 μm), content (lipid, RNA, DNA, protein) and potential function (s). Many isolation techniques systematically throw large EVS in the early stages of the small or exosomatic isolation protocols. We describe here a standardized method for isolating large eV from medulloblastoma cells and examine the expression of the EV marker and the diameter using the imaging flow cytometry. Our approach allows the characterization of each large EVS as an individual event, decorated with several fluorescent conjugal markers with the additional advantage of visualizing each event to ensure an application of robust gage strategies.

Methods: We describe the isolation of the step and characterization of a subset of large EVS from the UW228-2 medulloblastoma cell line evaluated by fluorescent light microscopy, transmission electron microscopy (TEM) and Tunable resistance detection (TRP). The viability of parental cells was evaluated by the Annexine V exposure by flow cytometry. Imagery flow cytometry (ImageReam Mark II) identified EVS by direct fluorescent membrane marking with orange cell mask (CMO) in conjunction with the EV markers. A rigorous guarantee algorithm based on the intensity of lateral diffusion and fluorescence has been applied and the expression of the EV markers CD63, CD9 and the lamp 1 evaluated.

Results: UW228-2 cells extend prolifically EVS upwards up to 6 μm. We show that the Imaging Flow Cytometer II allows a robust and reproducible analysis of the large EVS, including the evaluation of the diameter. We also demonstrate a correlation between the increase in the size of the EV and the co-expression of the filtered markers.

Total RNA Isolation Kit II

FATRS--001 100 preps
EUR 308

Total RNA Isolation Kit II

FATRS--050 50 preps
EUR 216

Easy3-Plant RNA Isolation Kit

FYG502-100P 100 Preps Ask for price

Easy3-Plant RNA Isolation Kit

FYG502-500P 500 Preps Ask for price

Total RNA Isolation Kit (Tissue)

P-9102 50 samples
EUR 347.25
Description: reagents widely cited

Total RNA Isolation Kit (Plant)

P-9104 50 samples
EUR 347.25
Description: kits suitable for this type of research

Rapid Bacteria RNA Isolation Kit

BS8625 50Preps
EUR 79.69
  • Product category: Molecular Biology Kits/RNA - Extraction/Bacteria

Rapid Blood RNA Isolation Kit

BT4182 10Preps
EUR 81.97
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

Rapid Blood RNA Isolation Kit

BT4183 50Preps
EUR 164.19
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

Rapid Blood RNA Isolation Kit

BT4184 250preps
EUR 506.75
  • Product category: Molecular Biology Kits/RNA - Extraction/Blood

Rapid Plant RNA Isolation Kit

PT4191 50Preps
EUR 79.69
  • Product category: Molecular Biology Kits/RNA - Extraction/Plant

RNA-easy Isolation Reagent

R701-01 100 ml
EUR 168

RNA-easy Isolation Reagent

R701-02 200 ml
EUR 212

Green RNA Lysis Kit 50

GREENE1-RNA 50pack
EUR 180
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RNA Lysis Kit 250

GREENE5-RNA 250pack
EUR 571
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Navy RNA Lysis Kit 50

NAVYE1-RNA 50pack
EUR 198
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Navy RNA Lysis Kit 250

NAVYE5-RNA 250pack
EUR 651
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Pink RNA Lysis Kit 50

PINKE1-RNA 50pack
EUR 178
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Pink RNA Lysis Kit 250

PINKE5-RNA 250pack
EUR 561
Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 50

REDE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

Red RNA Lysis Kit 250

REDE5-RNA 250pack
EUR 622
Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 50

YELLOWE1-RNA 50pack
EUR 192
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RNA Lysis Kit 250

YELLOWE5-RNA 250pack
EUR 624
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

5E GREEN RNA Lysis Kit 100

GREEN5E100-RNA 100pack
EUR 386
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 1000, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

5E GREEN RNA Lysis Kit 20

GREEN5E20-RNA 20pack
EUR 138
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 50

GREENR1-RNA 50pack
EUR 184
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

Green RINO RNA Lysis Kit 250

GREENR5-RNA 250pack
EUR 587
Description: Bead lysis kits for the homogenization of small, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with beads. RNase free.

5E Navy RNA Lysis Kit 100

NAVY5E100-RNA 100pack
EUR 453
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

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NAVY5E20-RNA 20pack
EUR 153
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

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NAVYR1-RNA 50pack
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Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

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NAVYR5-RNA 250pack
EUR 666
Description: Bead lysis kits for the homogenization of large, tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stainless steel beads. RNase free.

5E PINK RNA Lysis Kit 100

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Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

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Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

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Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

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PINKR5-RNA 250pack
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Description: Bead lysis kits for the homogenization of small, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

5E RED RNA Lysis Kit 100

RED5E100-RNA 100pack
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Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 100, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

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Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 20, 5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. RNase free.

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Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

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REDR5-RNA 250pack
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Description: Bead lysis kits for the homogenization of large, soft or medium-tough samples. Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

YELLOW RINO RNA Lysis Kit 50

YELLOWR1-RNA 50pack
EUR 199
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

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YELLOWR5-RNA 250pack
EUR 656
Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL RINO screw-cap tubes prefilled with stabilized ceramic beads. RNase free.

Soil RNA Isolation Mini Kit (50prep)

FASRK-001 50 preps
EUR 150

Soil RNA Isolation Mini Kit (100prep)

FASRK-100 100 preps
EUR 187

Broad Range Total RNA Isolation Kit

K1341050 1 kit
EUR 266
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

FastPure Cell/Tissue Total RNA Isolation Kit

RC101 50 rxn
EUR 229

PureXtract RNAsol RNA Isolation Solution, LS

R6103-120 2X60ml
EUR 286

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)

P101NGS NULL
EUR 0

FastPure Plant Total RNA Isolation Kit (Polysaccharides/Polyphenolics-Rich)

RC401 50 rxn
EUR 236

Mitochondria Isolation Kit

AR0156 1 kit
EUR 106

miRNA Isolation Kit

FAMIK--001 Rxns: 100
EUR 332
Description: Contents of the kit:
  • Rxns:100Lysis
  • Buffer-10 ml
  • Acid-Phenol-10 ml
  • RNA Column and Collection Tube-100 sets
  • Wash Buffer-10 ml
  • Release Buffer-0.5 ml

miRNA Isolation Kit

FAMIK--002 Rxns: 50
EUR 223

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

MicroRNA Isolation Kit

KS341025 1 kit
EUR 256
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Preadipocyte Isolation Kit

K583-5
EUR 533

Microsome Isolation Kit

K249-50
EUR 528

Endosome Isolation Kit

P528 NULL
EUR 0

ExoQuick Exosome Isolation and RNA Purification kit (for Serum and Plasma)

EQ806A-1 20 preps
EUR 554

ExoQuick Exosome Isolation and RNA Purification kit (for Tissue Culture Media)

EQ806TC-1 10 preps
EUR 554

Apoptotic Cell Isolation Kit

55R-1349 30 units
EUR 729
Description: Apoptotic Cell Isolation Kit for use in the research laboratory

Mitochondrial DNA Isolation Kit

55R-1361 50 assays
EUR 825
Description: Mitochondrial DNA Isolation Kit for use in the research laboratory

Genomic DNA Isolation Kit

55R-1362 50 assays
EUR 385
Description: Genomic DNA Isolation Kit for use in the research laboratory

Cell Mitochondria Isolation Kit

abx090630-50100tests 50-100 tests
EUR 258
  • Shipped within 5-10 working days.

Tissue Mitochondria Isolation Kit

abx090631-50100assays 50-100 assays
EUR 258
  • Shipped within 5-10 working days.

Saliva DNA Isolation Kit

K5011050 1 kit
EUR 256

Urine DNA Isolation Kit

K5011150 1 kit
EUR 256

Stool DNA Isolation Kit

K5011250 1 kit
EUR 256

Serum DNA Isolation Kit

K5018100 1 kit
EUR 360

Lipopolysaccharide (LPS) Isolation Kit

K438-10
EUR 278

Mitochondrial DNA Isolation Kit

K280-50
EUR 588

Genomic DNA Isolation Kit

K281-50
EUR 272

Yeast Nuclei Isolation Kit

K289-50
EUR 392

Apoptotic Cell Isolation Kit

K258-30
EUR 468

Yeast Mitochondria Isolation Kit

K259-50
EUR 419

Mitochondrial DNA Isolation Kit

K2117-50 50 assays
EUR 599

Genomic DNA Isolation Kit

K2118-50 50 assays
EUR 321

ExoPure? Isolation Kit   (Urine)

K1240-10
EUR 697

ExoPure? Isolation Kit   (Urine)

K1240-2
EUR 403

Lipid Droplet Isolation Kit

MET-5011 50 preps
EUR 415
Description: Lipid droplets are lipid rich organelles found in the adipose tissue of eukaryotes. They function to regulate the hydrolysis and storage of neutral lipids and serve as storage for cholesterol and acyl-glycerols. Lipid droplets have also been associated with inflammatory responses, obesity, atherosclerosis, and cancer.

Frit Kit

FRIT-KIT 1each
EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 551

Circulating Nuleic Acid Isolation Kit

FACFK-050 50 preps
EUR 491

Circulating Nuleic Acid Isolation Kit

FACFK-100 100 preps
EUR 825

Easy3-Total NucleicAcid Isolation Kit

FYG504-100ML 100 ml Ask for price

Easy3-Total NucleicAcid Isolation Kit

FYG504-500ML 500 ml Ask for price

Whole Blood DNA Isolation Kit

K528-100
EUR 376

Org Frontier? Chloroplast Isolation Kit

K468-10
EUR 555

Bacterial Genomic DNA Isolation Kit

K309-100
EUR 376

Apoptotic DNA Ladder Isolation Kit

K2045-50 50 assays
EUR 502

Cell Surface Protein Isolation Kit

K295-10
EUR 501

EZExtract? Core Histone Isolation Kit

K234-100
EUR 262

OrgFrontier? Plasma Membrane Isolation Kit

K414-10
EUR 566

ExoPure? Isolation Kit   (Cell Media)

K1237-10
EUR 664

ExoPure? Isolation Kit   (Cell Media)

K1237-2
EUR 392

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10
EUR 697

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2
EUR 392

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10
EUR 697

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2
EUR 403

Apoptotic DNA Ladder Isolation Kit

K170-50
EUR 468

Detergent-Free Nuclei Isolation Kit

P524-2 NULL
EUR 0

Detergent-Free Nuclei Isolation Kit

P524-20 NULL
EUR 0

Detergent-Free Nuclei Isolation Kit

P524-80 NULL
EUR 0

Lysosome Isolation Kit (20 tests)

P534 NULL
EUR 0

Mouse Brain Microvessel Isolation Kit

P750-4 NULL
EUR 0

Exosome Isolation kit (for urine)

P120L NULL
EUR 0

Exosome Isolation kit (for urine)

P120S NULL
EUR 0

FitAmp Gel DNA Isolation Kit

P-1007 100 Samples
EUR 270.4
Description: The best epigenetics products

FitAmp Urine DNA Isolation Kit

P-1017 100 Samples
EUR 395.1
Description: kits suitable for this type of research

ChromaFlash Chromatin Isolation & Shearing Kit

P-2023 100 Preperations
EUR 270.4
Description: kits suitable for this type of research

XCF Exosomal DNA Isolation Kit

XCF200A-1 20 rxn
EUR 386
  • Category: Exosome

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PSEUDOMONAS ISOLATION AGAR

P16-114-10kg 10 kg
EUR 1715

PSEUDOMONAS ISOLATION AGAR

P16-114-2kg 2kg
EUR 412

PSEUDOMONAS ISOLATION AGAR

P16-114-500g 500 g
EUR 148

PSEUDOMONAS ISOLATION BROTH

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PSEUDOMONAS ISOLATION BROTH

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PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 266

Mouse Cartilage PrimaCell: Normal Articular Cartilage

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Human Cartilage PrimaCell: Normal Articular Cartilage

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Orange Lysis Kit 50

ORANGEE1-RNA 50pack
EUR 165
Description: Bead lysis kits for extracting bacteria or generating single cell suspensions from tissue samples. Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Orange Lysis Kit 250

ORANGEE5-RNA 250pack
EUR 537
Description: Bead lysis kits for extracting bacteria or generating single cell suspensions from tissue samples. Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stainless steel beads. RNase free.

Orange RINO Lysis Kit 50

ORANGER1-RNA 50pack
EUR 169
Description: Bead lysis kits for extracting bacteria or generating single cell suspensions from tissue samples. Pack of 50, 1.5mL RINO tubes prefilled with stainless steel beads. RNase free.

Orange RINO Lysis Kit 250

ORANGER5-RNA 250pack
EUR 554
Description: Bead lysis kits for extracting bacteria or generating single cell suspensions from tissue samples. Pack of 250, 1.5mL RINO tubes prefilled with stainless steel beads. RNase free.

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1110
  • Category: Cas9

FastPure Bacteria DNA Isolation Mini Kit

DC103 100 rxn
EUR 177

FastPure Plant DNA Isolation Mini Kit

DC104 50 rxn
EUR 160

FastPure FFPE DNA Isolation Mini Kit

DC105 50 rxn
EUR 201

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 411
  • Shipped within 5-10 working days.

Soil DNA Isolation Mini Kit (50prep)

FASOI-001 50 preps
EUR 158

Soil DNA Isolation Mini Kit (100prep)

FASOI-001-1 100 preps
EUR 201

Soil DNA Isolation Midi Kit (24prep)

FASOI-002 24 preps
EUR 216

Easy3-Plant Genomic DNA Isolation Kit

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Easy3-Plant Genomic DNA Isolation Kit

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Blood and Serum DNA Isolation Kit

K5017100 1 kit
EUR 360

Human Whole Blood Monocyte Isolation Kit

K933-30
EUR 376

Mammalian Cell Genomic DNA Isolation Kit

K967-100
EUR 381

Plant Tissue Genomic DNA Isolation Kit

K316-100
EUR 376

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10
EUR 751

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2
EUR 425

Conclusions: We have developed a labeling and gating strategy strictly capable of exploring the eV marker expression (CD63, CD9 and LAMP1) on individual EV in a largely heterogeneous population. Taken together, the data presented here strongly support the value of the exploration of large EVS in clinical samples for potential biomarkers, useful in the monitoring of diagnosis and disease surveillance.